The homologous chromosomes in each bivalent are separated and move to the opposite poles of the cell.
Mol Biol Cell 24: J Cell Sci 113: Prelude to a division. Keep playing.
Already registered? The centrosomes organise the production of microtubules that form the spindle fibres that constitute the mitotic spindle. Kinetochore—microtubule attachments are abolished in prophase of the first meiotic division because Ndc80, which provides the main microtubule-binding activity of the kinetochore, is destabilized in an Ipl1-dependent manner Miller et al. Recombination starts in this context with the action of the endonuclease Spo11, which introduces deliberate and stochastic double-strand breaks along the chromosome Keeney et al.
Nicklas R. Whether meiotic chromosomes possess spring-like behavior at the point of tension, as observed for pericentromeres in mitosis, and whether increased structural rigidity of chromosome arms is required to allow force transduction along them remain questions for the future.
Who are you? The generation of such arrays has been modeled as a recombinational process of random unequal exchange . Starting Original Price. In multicelluar eukaryotes, centromeres are typically composed of highly homogeneous tandem repeats that evolve rapidly despite their highly conserved function .
Thus, the kinetochore both controls and harnesses the force generated by microtubules to direct chromosome segregation. View Article Google Scholar 10.
C Tension is generated when the pulling force of the microtubule is counteracted by cohesion blue rings holding sister chromatids together see the text.
Mol Biol Cell 20: Chromosome Res 17: How does the kinetochore use the chemical energy of microtubule depolymerization to power chromosome movement? Skip to content.
Try it risk-free No obligation, cancel anytime. Chromosome Banding: PLoS Genet 2: They can switch from polymerization to depolymerization catastrophe or vice versa rescue Fig. Our understanding of the properties and function of the kinetochore has been enhanced by several lines of investigation: